Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program

@article{Muruganandan2008AdipocyteDO,
  title={Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program},
  author={Shanmugam Muruganandan and Alexandra A. Roman and Christopher J. Sinal},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={66},
  pages={236-253}
}
  • Shanmugam Muruganandan, Alexandra A. Roman, Christopher J. Sinal
  • Published 2008
  • Medicine, Biology
  • Cellular and Molecular Life Sciences
  • Abstract.Bone marrow mesenchymal stem cells (MSCs) are multipotent cells, which among other cell lineages, give rise to adipocytes and osteoblasts. Within the bone marrow, the differentiation of MSCs into adipocytes or osteoblasts is competitively balanced; mechanisms that promote one cell fate actively suppress mechanisms that induce the alternative lineage. This occurs through the cross talk between complex signaling pathways including those derived from bone morphogenic proteins (BMPs… CONTINUE READING

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