Adipocyte differentiation from the inside out

@article{Rosen2006AdipocyteDF,
  title={Adipocyte differentiation from the inside out},
  author={Evan D. Rosen and Ormond A. MacDougald},
  journal={Nature Reviews Molecular Cell Biology},
  year={2006},
  volume={7},
  pages={885-896}
}
Improved knowledge of all aspects of adipose biology will be required to counter the burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the past few years with emphasis on the intersection between extracellular signals and the transcriptional cascade that regulates adipocyte differentiation. Many different events contribute to the commitment of a mesenchymal stem cell to the adipocyte lineage including the coordination of a complex network of transcription… Expand
Adipogenesis at a glance
The formation of adipocytes from precursor stem cells involves a complex and highly orchestrated programme of gene expression. Our understanding of the basic network of transcription factors thatExpand
Adipogenesis and WNT signalling
TLDR
Manipulating the WNT pathway to alter adipose cellular makeup constitutes an attractive drug-development target to combat obesity-associated metabolic complications. Expand
Metabolism, Endocrinology and Differentiation of White Adipose Tissue
TLDR
The advances in research on the white adipose tissue physiology, with emphasis on its role on endocrine, metabolic and inflammatory process, as well as the adipogenic process are shown. Expand
Forming functional fat: a growing understanding of adipocyte differentiation
TLDR
Improving the understanding of these mechanisms may allow us to identify therapeutic targets against metabolic diseases that are rapidly becoming epidemic globally. Expand
Endocrinology and Differentiation of White Adipose Tissue
In the last two decades there has been a growing interest in the scientific community to study the function of adipose tissue (AT), partly due to concerns about obesity and its metabolic consequencesExpand
Transdifferentiation of adipocytes to osteoblasts: potential for orthopaedic treatment
TLDR
As both adipocytes and osteoblasts originate from the same pool of mesenchymal stem cells, increasing clinical evidence has emerged of the plasticity between the two lineages, but little is known of the underlying mechanisms. Expand
Differentiation of Adipocytes in Monolayer from Mouse Embryonic Stem Cells.
TLDR
This chapter describes a detailed protocol that is optimized for mouse embryonic stem cells to differentiate the pluripotent embryonic stem cell to adipocytes, resulting in a homogenous adipocyte monolayer culture that can be used for several applications including developmental and pharmacological research. Expand
Epigenetic regulation of adipocyte differentiation and adipogenesis
TLDR
This review focuses on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis, which can be divided into two processes: determination and differentiation. Expand
Developmental origin of adipocytes: new insights into a pending question
TLDR
Surprising findings that have recently emerged from both embryonic stem cells and lineage‐tracing studies in vivo are summarized, unravelling an unsuspected developmental origin for MSCs and adipocytes in the neural crest. Expand
Inhibition of adipogenesis: a new job for the ER Ca2+ pool
  • J. Meldolesi
  • Biology, Medicine
  • The Journal of cell biology
  • 2008
TLDR
This study demonstrates that this process of differentiation of adipocytes from mesenchymal multipotent cells through adipocyte precursors is repressed by increasing intracellular Ca2+, which, in turn, is dependent on the expression of calreticulin, the major Ca2+-binding protein of the endoplasmic reticulum lumen. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 166 REFERENCES
Adipogenesis: forces that tip the scales
TLDR
Recent contributions to the field are described and factors that probably play a role in vivo are described, including Wnt, transforming growth factor beta, inflammatory cytokines and prostaglandin F(2alpha). Expand
Notch pathway is dispensable for adipocyte specification
TLDR
It is concluded that the “canonical” Notch signaling pathway is dispensable for adipocyte specification and differentiation from either mesenchymal or epithelial progenitors. Expand
C/EBP induces adipogenesis through PPAR: a unified pathway
PPAR and C/EBP are critical transcription factors inadipogenesis, but the precise role of these proteins hasbeen difficult to ascertain because they positively regu-late each other’s expression.Expand
Molecular mechanisms of adipocyte differentiation and inhibitory action of pref-1.
  • C. Smas, H. Sul
  • Chemistry, Medicine
  • Critical reviews in eukaryotic gene expression
  • 1997
TLDR
Transcription factors PPAR gamma and C/EBP have been shown to transactivate some of the adipocyte-expressed genes, and these nuclear factors may synergistically function in adipocyte lineage determination and differentiation. Expand
Adipose Development: From Stem Cell to Adipocyte
TLDR
Following commitment to the adipose lineage, growth-arrested preadipocytes can differentiate to adipocytes by treatment with insulin-like growth factor 1, glucocorticoid and an agent that increases cAMP level. Expand
The forkhead transcription factor Foxo1 regulates adipocyte differentiation.
TLDR
It is proposed that Foxo1 plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes adipocyte differentiation. Expand
The role of MAPKs in adipocyte differentiation and obesity.
TLDR
It appears now that a fine tuning of the MAPKs regulates both normal and pathological adipogenesis, and the precise understanding of the cascade of these molecular events and the way to regulate them will be certainly crucial in order to efficiently fight obesity. Expand
Fibroblast growth factor 1: a key regulator of human adipogenesis.
TLDR
It is demonstrated that coculture of human preadipocytes with MVECs significantly increasesPreadipocyte differentiation, evidenced by dramatically increased triacylglycerol accumulation and glycerol-3-phosphate dehydrogenase activity compared with controls. Expand
Function of GATA transcription factors in preadipocyte-adipocyte transition.
TLDR
It is shown that murine GATA-2 and Gata-3 are specifically expressed in white adipocyte precursors and that their down-regulation sets the stage for terminal differentiation. Expand
EPAS 1 Promotes Adipose Differentiation in 3 T 3L 1 Cells *
Adipose differentiation is regulated by several transcription factors, such as the CAAT/enhancer-binding protein family and peroxisome proliferator activator (PPAR) 2. Several recent studies haveExpand
...
1
2
3
4
5
...