Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.

@article{Ogawa2010AdipocytederivedMC,
  title={Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.},
  author={Rumiko Ogawa and Chie Tanaka and Masahiro Sato and Haruka Nagasaki and Kazuto Sugimura and Katsuzumi Okumura and Yoshimi Nakagawa and Naohito Aoki},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={398 4},
  pages={723-9}
}
We have recently found that 3T3-L1 adipocytes secrete microvesicles, known as adipocyte-derived microvesicles (ADMs), with angiogenic activity. In this study, we found that ADMs contain RNA without typical 28S and 18S ribosomal RNA inside the vesicles. Microarray analysis revealed that ADMs contain approximately 7000 mRNAs and 140 microRNAs. Most of transcripts for adipocyte-specific and dominant genes were contained in the ADMs, and their abundance was mostly correlated with that in the donor… CONTINUE READING
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