Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice.

@article{Yiannikouris2012AdipocyteDO,
  title={Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice.},
  author={Frederique B. Yiannikouris and Manisha Gupte and Kelly Putnam and Sean E. Thatcher and Richard J. Charnigo and Debra L. Rateri and Alan Daugherty and Lisa A. Cassis},
  journal={Hypertension},
  year={2012},
  volume={60 6},
  pages={1524-30}
}
Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice. Adipocytes express angiotensinogen and secrete angiotensin peptides. We hypothesize that adipocyte-derived angiotensin II mediates obesity-induced increases in systolic blood pressure in male high fat-fed C57BL/6 mice. Systolic blood pressure was measured by radiotelemetry during week 16 of low-fat or high-fat feeding in Agt(fl/fl) and… CONTINUE READING
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