Adipocyte death, adipose tissue remodeling, and obesity complications.

  title={Adipocyte death, adipose tissue remodeling, and obesity complications.},
  author={Katherine J. Strissel and Zlatina S. Stancheva and Hideaki Miyoshi and James W. Perfield and Jason Defuria and Zoe Jick and Andrew S Greenberg and Martin S. Obin},
  volume={56 12},
OBJECTIVE We sought to determine the role of adipocyte death in obesity-induced adipose tissue (AT) inflammation and obesity complications. RESEARCH DESIGN AND METHODS Male C57BL/6 mice were fed a high-fat diet for 20 weeks to induce obesity. Every 4 weeks, insulin resistance was assessed by intraperitoneal insulin tolerance tests, and epididymal (eAT) and inguinal subcutaneous AT (iAT) and livers were harvested for histological, immunohistochemical, and gene expression analyses. RESULTS… CONTINUE READING
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