Adipocyte activation of cancer stem cell signaling in breast cancer.

  title={Adipocyte activation of cancer stem cell signaling in breast cancer.},
  author={Benjamin Wolfson and Gabriel L Eades and Qun Zhou},
  journal={World journal of biological chemistry},
  volume={6 2},
Signaling within the tumor microenvironment has a critical role in cancer initiation and progression. Adipocytes, one of the major components of the breast microenvironment, have been shown to provide pro-tumorigenic signals that promote cancer cell proliferation and invasiveness in vitro and tumorigenicity in vivo. Adipocyte secreted factors such as leptin and interleukin-6 (IL-6) have a paracrine effect on breast cancer cells. In adipocyte-adjacent breast cancer cells, the leptin and IL-6… CONTINUE READING


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