Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase.

@article{Urbanet2015AdipocyteMR,
  title={Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase.},
  author={Riccardo Urbanet and Aur{\'e}lie Nguyen Dinh Cat and Alessandra Feraco and Nicolas Venteclef and Soumaya El Mogrhabi and Catalina Sierra-Ramos and Diego Alvarez de la Rosa and Gail K. Adler and Didier Quilliot and Patrick Rossignol and Francesco Fallo and Rhian M Touyz and Fr{\'e}d{\'e}ric Jaisser},
  journal={Hypertension},
  year={2015},
  volume={66 1},
  pages={149-57}
}
Metabolic syndrome is a major risk factor for the development of diabetes mellitus and cardiovascular diseases. Pharmacological antagonism of the mineralocorticoid receptor (MR), a ligand-activated transcription factor, limits metabolic syndrome in preclinical models, but mechanistic studies are lacking to delineate the role of MR activation in adipose tissue. In this study, we report that MR expression is increased in visceral adipose tissue in a preclinical mouse model of metabolic syndrome… CONTINUE READING