Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4

@article{Wang2017AdipocyteLK,
  title={Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4},
  author={Yangmeng Wang and Esther Paulo and Dongmei Wu and Yixuan Wu and Wendong Huang and A. S. Chawla and Biao Wang},
  journal={Diabetes},
  year={2017},
  volume={66},
  pages={2952 - 2963}
}
Uncoupling protein 1+ beige adipocytes are dynamically regulated by environment in rodents and humans; cold induces formation of beige adipocytes, whereas warm temperature and nutrient excess lead to their disappearance. Beige adipocytes can form through de novo adipogenesis; however, how “beiging” characteristics are maintained afterward is largely unknown. In this study, we show that beige adipocytes formed postnatally in subcutaneous inguinal white adipose tissue lost thermogenic gene… Expand
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TLDR
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