Adipocyte-Like Differentiation in a Posttreatment Embryonal Rhabdomyosarcoma

  title={Adipocyte-Like Differentiation in a Posttreatment Embryonal Rhabdomyosarcoma},
  author={Dana Balitzer and Timothy H McCalmont and Andrew E Horvai},
  booktitle={Case reports in pathology},
We describe a 16-year-old boy with rhabdomyosarcoma, consistent with embryonal subtype, of the lower extremity who received systemic neoadjuvant chemotherapy and subsequent excision. Microscopic sections of the postchemotherapy excision demonstrated diffuse, prominent, and immature adipocyte-like differentiation, in addition to skeletal muscle differentiation. Adipocyte-like differentiation was confirmed by a combination of positive Oil Red O and adipophilin immunohistochemical staining. To our… CONTINUE READING
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