Adhesive dynamics simulation of neutrophil arrest with deterministic activation.

  title={Adhesive dynamics simulation of neutrophil arrest with deterministic activation.},
  author={Ellen F Krasik and Ka Lai Yee and Daniel A. Hammer},
  journal={Biophysical journal},
  volume={91 4},
The transition from rolling to firm adhesion is a key element of neutrophil activation and essential to the inflammatory response. Although the molecular mediators of rolling and firm adhesion are known to be selectins and beta2 -integrins, respectively, the precise dynamic mechanism by which these ligands facilitate neutrophil arrest remains unknown. Recently, it has been shown that ligation of E-selectin can stimulate the firm adhesion of neutrophils via a MAP-kinase cascade. To study the… CONTINUE READING
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Rolling adhesion through an extended conformation of integrin a(L)b(2) and relation to a I and b I-like domain interaction

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Effect of immobilized IL-8 on neutrophil rolling and adhesion

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Adhesive Dynamics Simulation of Neutrophil Arrest with Deterministic Activation

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  • 2006

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