Adhesive and signaling functions of cadherins and catenins in vertebrate development.

@article{Stepniak2009AdhesiveAS,
  title={Adhesive and signaling functions of cadherins and catenins in vertebrate development.},
  author={Ewa Stepniak and Glenn L Radice and Valeri Vasioukhin},
  journal={Cold Spring Harbor perspectives in biology},
  year={2009},
  volume={1 5},
  pages={
          a002949
        }
}
Properly regulated intercellular adhesion is critical for normal development of all metazoan organisms. Adherens junctions play an especially prominent role in development because they link the adhesive function of cadherin-catenin protein complexes to the dynamic forces of the actin cytoskeleton, which helps to orchestrate a spatially confined and very dynamic assembly of intercellular connections. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are… CONTINUE READING

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