Adhesive and degradative properties of human placental cytotrophoblast cells in vitro

@article{Fisher1989AdhesiveAD,
  title={Adhesive and degradative properties of human placental cytotrophoblast cells in vitro},
  author={Susan J. Fisher and T Y Cui and Lei Zhang and Leslie Hartman and K T Grahl and Geoff Yu Zhang and J. J. Tarpey and Caroline H. Damsky},
  journal={The Journal of Cell Biology},
  year={1989},
  volume={109},
  pages={891 - 902}
}
Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties. Thus, during early pregnancy fetal cytotrophoblast cells invade the uterus and its arterial network. This process peaks during the twelfth week of pregnancy and declines rapidly thereafter, suggesting that the highly specialized, invasive behavior… CONTINUE READING