Adhesive Ligand Binding to Integrin XXb / 3 Stimulates Tyrosine Phosphorylation of Novel Protein Substrates before Phosphorylation of pp 125 FAK

Abstract

Tyrosine phosphorylation of multiple platelet proteins is stimulated by thrombin and other agonists that cause platelet aggregation and secretion. The phosphorylation of a subset of these proteins, including a protein tyrosine kinase, pp125 FAK, is dependent on the platelet aggregation that follows fibrinogen binding to integrin C~m~3. In this report, we… (More)

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