Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

@article{Koopman1994AdhesionTT,
  title={Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.},
  author={Gerrit Koopman and Robert M. J. Keehnen and Ernst Lindhout and Walter S. Newman and Yoji Shimizu and Gijs A van Seventer and Cornelis de Groot and Steven T. Pals},
  journal={Journal of immunology},
  year={1994},
  volume={152 8},
  pages={3760-7}
}
In the germinal center (GC), B cells are either selected to become memory cells or are eliminated through the process of programmed cell death. FDC which are intimately associated with the GC B cells are thought to be important in this selection process. Previously, we have shown that the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and VLA-4 (CD49d)-VCAM-1 (CD106) adhesion pathways are involved in FDC-B cell interaction. In the present study, we have explored whether these adhesive interactions contribute… CONTINUE READING
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