Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia.

@article{Brown2004AdhesionOP,
  title={Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia.},
  author={Tod A. Brown and Tai Mei Yang and Tatiana Zaitsevskaia and Yuping Xia and Clarence A. Dunn and Randy O. Sigle and Beatrice S. Knudsen and William Gene Carter},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 15},
  pages={14772-83}
}
Suspension of cultured human foreskin keratinocytes (HKs) with trypsin phosphorylates tyrosine residues on an 80-kDa membrane glycoprotein, p80 (Xia, Y., Gil, S. G., and Carter, W. G. (1996) J. Cell Biol. 132, 727-740). Readhesion dephosphorylates p80. Sequencing of a p80 cDNA established identity to CUB domain-containing protein 1 (CDCP1), a gene elevated in carcinomas. CDCP1/p80 cDNA encodes three extracellular CUB domains, a transmembrane domain, and two putative cytoplasmic Tyr… CONTINUE READING