Adhesion of sickle cells to vascular endothelium is critically dependent on changes in density and shape of the cells.

@article{Kaul1994AdhesionOS,
  title={Adhesion of sickle cells to vascular endothelium is critically dependent on changes in density and shape of the cells.},
  author={Dhananjay K. Kaul and Di Chen and Jun Zhan},
  journal={Blood},
  year={1994},
  volume={83 10},
  pages={
          3006-17
        }
}
Experiments were performed to explore whether adhesion differences among different density sickle (SS) cells are mainly caused by deformability characteristics attendant to density variations, which could affect their surface contacts with the endothelium, or caused by any changes in their membrane surface (eg, receptors). Also, what is the contribution of morphologic attributes of SS cells in adhesive and obstructive events? To resolve these issues, controlled modifications of cell density… CONTINUE READING

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