Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A.

@article{Takada1991AdhesionOH,
  title={Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A.},
  author={Akikazu Takada and Kazuo Ohmori and Nobuyuki Takahashi and K Tsuyuoka and Akio Yago and Koichi Zenita and Atsuhiko Hasegawa and Reiji Kannagi},
  journal={Biochemical and biophysical research communications},
  year={1991},
  volume={179 2},
  pages={713-9}
}
Recently the lectin-like domain on ELAM-1 (endothelial leukocyte adhesion molecule-1) was shown to recognize a carbohydrate antigen, sialyl Lewis x. In this paper we demonstrate, by a series of inhibition experiments utilizing specific monoclonal antibodies and pure glycolipid preparations, that the sialyl Lewis a antigen serves as a specific ligand for ELAM-1 as well as sialyl Lewis x and plays a significant role in the ELAM-1-mediated binding of human cancer cells to activated endothelial… CONTINUE READING
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