Adhesion of Staphylococcus aureus to surface-bound platelets: role of fibrinogen/fibrin and platelet integrins.

@article{Herrmann1993AdhesionOS,
  title={Adhesion of Staphylococcus aureus to surface-bound platelets: role of fibrinogen/fibrin and platelet integrins.},
  author={Marita Herrmann and Qiuliang Lai and Ralph M. Albrecht and Deane F Mosher and Richard A. Proctor},
  journal={The Journal of infectious diseases},
  year={1993},
  volume={167 2},
  pages={312-22}
}
Platelets adhering to artificial or biologic surfaces have been implicated in the pathogenesis of catheter infections or endocarditis; however, the ligands involved in Staphylococcus aureus interaction with adherent platelets remain incompletely understood. Radiolabeled S. aureus Cowan I were incubated with purified platelets adherent to polymethylmethacrylate (PMMA) coverslips and washed, and adhesion was determined. Platelets promoted adhesion of S. aureus approximately 30-fold compared with… CONTINUE READING

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