Adhesion of Monocytes to Arterial Endothelium and Initiation of Atherosclerosis Are Critically Dependent on Vascular Cell Adhesion Molecule-1 Gene Dosage

@article{Dansky2001AdhesionOM,
  title={Adhesion of Monocytes to Arterial Endothelium and Initiation of Atherosclerosis Are Critically Dependent on Vascular Cell Adhesion Molecule-1 Gene Dosage},
  author={H. Dansky and C. Barlow and C. Lominska and J. Sikes and C. Kao and J. Weinsaft and M. Cybulsky and J. Smith},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association},
  year={2001},
  volume={21},
  pages={1662-1667}
}
  • H. Dansky, C. Barlow, +5 authors J. Smith
  • Published 2001
  • Biology, Medicine
  • Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association
Vascular cell adhesion molecule-1 (VCAM-1/ Vcam1) is a cytokine-inducible member of the immunoglobulin gene superfamily that is expressed by arterial endothelial cells in regions predisposed to atherosclerosis and at borders of atherosclerotic plaques. To determine whether VCAM-1 expression regulates atherosclerotic lesion formation, we crossed Vcam1 domain 4–deficient (D4D) mice, which partially circumvent the embryonic lethality of Vcam1 null mice, with apolipoprotein E null (Apoe−/−) mice… Expand
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