Adhesion molecules in cancer: the role of integrins.

  title={Adhesion molecules in cancer: the role of integrins.},
  author={R L Juliano and Julie A Varner},
  journal={Current opinion in cell biology},
  volume={5 5},
It has been known for some time that cell adhesion receptors, including members of the integrin family, play an important role in the biology of tumors. Until recently, most of the emphasis in this area of research has concerned the functioning of integrins as adhesive molecules in the invasive and metastatic behavior of malignant cells. Now it has become clear that integrins can function as true receptors capable of transducing signals to the cell interior. Tyrosine phosphorylation seems to be… CONTINUE READING

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