Adhesion-induced tyrosine phosphorylation of the p130 src substrate.

  title={Adhesion-induced tyrosine phosphorylation of the p130 src substrate.},
  author={Leslie A. Petch and Susanne M. Bockholt and Amy H. Bouton and John T. Parsons and Keith Burridge},
  journal={Journal of cell science},
  volume={108 ( Pt 4)},
Adhesion of cells to the extracellular matrix leads to an increase in the tyrosine phosphorylation of a specific set of proteins, three of which have now been identified as the focal adhesion proteins pp125FAK, paxillin and tensin. In addition, we have previously noted the adhesion-induced tyrosine phosphorylation of a fourth protein, with an apparent molecular mass of 130. As in the case of FAK, paxillin and tensin, a 130 kDa protein is also found to be highly tyrosine phosphorylated in Rous… CONTINUE READING


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