Adhesion-dependent multicellular drug resistance.

  title={Adhesion-dependent multicellular drug resistance.},
  author={Shane K. Green and Andrea Frankel and Robert S. Kerbel},
  journal={Anti-cancer drug design},
  volume={14 2},
Herein we review studies demonstrating resistance manifested at the multicellular level, a phenomenon referred to as intrinsic or acquired multicellular resistance (MR). In addition, due to the fact that such resistance can be recapitulated in vitro only when cells are adhered to one another in a three-dimensional culture context, we examine the roles of cell adhesion molecules and how they may contribute directly or indirectly to MR. Finally, we suggest an experimental approach to circumvent… CONTINUE READING

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