Adhesion-contractile balance in myocyte differentiation.

  title={Adhesion-contractile balance in myocyte differentiation.},
  author={Maureen A. Griffin and Shamik Sen and H Lee Sweeney and Dennis E Discher},
  journal={Journal of cell science},
  volume={117 Pt 24},
Tissue cells generally pull on their matrix attachments and balance a quasi-static contractility against adequate adhesion, but any correlation with and/or influence on phenotype are not yet understood. Here, we begin to demonstrate how differentiation state couples to actomyosin-based contractility through adhesion and substrate compliance. Myotubes are differentiated from myoblasts on collagen-patterned coverslips that allow linear fusion but prevent classic myotube branching. Post-fusion… CONTINUE READING
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