Adhesin activity of Leptospira interrogans lipoprotein identified by in vivo and in vitro shotgun phage display.

@article{Lima2013AdhesinAO,
  title={Adhesin activity of Leptospira interrogans lipoprotein identified by in vivo and in vitro shotgun phage display.},
  author={Swiany Silveira Lima and Ana Tung Ching Ching and Regiane Degan F{\'a}varo and Josefa B Da Silva and Maria Leonor S Oliveira and Eliedson Rafael de Carvalho and Patr{\'i}cia A E Abreu and Silvio de Arruda Vasconcellos and P L Ho},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={431 2},
  pages={
          342-7
        }
}
Leptospira interrogans causes leptospirosis, one of the most common zoonotic diseases in the world. This pathogenic spirochete is able to bind to extracellular matrix, to express virulent factors and to cause host death. Until now, there is no effective human vaccine for the disease. Shotgun phage display genomic libraries of L. interrogans were constructed and used for in vivo biopanning in hamsters and screened for ligands able to bind to LLC-PK1 epithelial cells. In both panning procedures… CONTINUE READING
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