Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo.

@article{Flemstrm1999AdherentSM,
  title={Adherent surface mucus gel restricts diffusion of macromolecules in rat duodenum in vivo.},
  author={Gunnar Flemstr{\"o}m and Anneli H{\"a}llgren and Olof Nylander and Lars Engstrand and Erik Wilander and Adrian Allen},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1999},
  volume={277 2},
  pages={G375-G382}
}
The aim of this study was to investigate the permeability of the adherent mucus gel layer in rat duodenum in vivo to macromolecules applied in the lumen. Rats were anesthetized with thiobarbiturate, and the duodenum was perfused with isotonic NaCl solution containing large-molecular-size secretagogues. Effects on mucosal [Formula: see text]secretion and blood-to-lumen51chromium-labeled EDTA clearance were used as indexes that compounds had migrated across the mucus layer. Exposure to a low… CONTINUE READING

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