Adherent-invasive Escherichia coli and Crohn's disease

@article{Barnich2007AdherentinvasiveEC,
  title={Adherent-invasive Escherichia coli and Crohn's disease},
  author={Nicolas Barnich and Arlette Darfeuille‐Michaud},
  journal={Current Opinion in Gastroenterology},
  year={2007},
  volume={23},
  pages={16–20}
}
Purpose of review The identification of mutations in the nucleotide oligomerization domain 2-encoding gene in patients with Crohn's disease suggests a link between the innate immune response to invasive bacteria and the development of Crohn's disease. Herein, we review reports concerning the association of pathogenic Escherichia coli with the intestinal mucosa of Crohn's disease patients. Recent findings Adherent-invasive E. coli were isolated from ileal biopsies of 36.4% of patients with ileal… 
Complete Genome Sequence of Crohn's Disease-Associated Adherent-Invasive E. coli Strain LF82
TLDR
LF82 genome analysis indicated that a number of genes, gene clusters and pathoadaptative mutations which have been acquired may play a role in virulence of AIEC strain LF82.
Complete genome sequence of Crohn ’ s disease-associated adherent-invasive E . coli strain LF 82 .
TLDR
The LF82 genome analysis indicated that a number of genes, gene clusters and pathoadaptative mutations which have been acquired may play a role in virulence of AIEC strain LF82, the reference strain of adherent-invasive E. coli associated with ileal Crohn's disease.
Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes
TLDR
The complete genome sequence of an AIEC is presented, revealing the genetic blueprint for this disease-associated E. coli pathotype and confirming a phylogenetic linkage between AIEC and extraintestinal pathogenic E. Escherichia coli causing urinary tract infections and neonatal meningitis.
Pathogenesis of adherent-invasive Escherichia coli.
TLDR
The role of AIEC as a pathobiont in the pathology of Crohn's disease is reviewed, the emerging link between AIEC and autophagy is described, and a model for AIEC pathogenesis is proposed.
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TLDR
These findings provide a link between microbes related to IBD, disruption of the intestinal epithelial cell barrier, and disease pathogenesis, and highlight the central role of the epithelium in mucosal defence.
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TLDR
This study provides new insight into how CD mucosa-associated E. coli isolates resist killing by mucosal macrophages through adaptation to the acidic, high oxidative environment within the macrophage phagolysosome.
Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis
TLDR
These findings provide evidence that chronic AIEC infections result in immunopathology similar to that seen in Crohn’s disease, and research into the host and bacterial genetics associated with AIEC-induced disease becomes more widely accessible.
Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases
TLDR
Further characterization of altered microbiota in patients with inflammatory bowel diseases and linking dysbiosis with host genetic alterations in immunoregulation, innate microbial killing and barrier function are critical, so that individualized treatments to increase beneficial commensals and their metabolic products and diminish deleterious species such as adherent/invasive E. coli can be tailored for defined patient subsets.
Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease
TLDR
Adherent invasive E. coli in adults at the time of first diagnosis are present at first diagnosis, suggesting that they may have a role in the early stages of disease onset.
Molecular diversity of Escherichia coli in the human gut: New ecological evidence supporting the role of adherent‐invasive E. coli (AIEC) in Crohn's disease
TLDR
The richness, abundance, diversity, and pathogenic features of E. coli and AIEC strains that colonize the intestinal mucosa are described and new data about ecological parameters of AIEC reinforces the implication ofAIEC in CD.
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