Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation.

@article{Bi2001AdherentEO,
  title={Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation.},
  author={Yanming Bi and Joscelyn M Seabold and Scott Geoffrey Kaar and Ashraf A. Ragab and Victor M. Goldberg and James M Anderson and Edward M. Greenfield},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2001},
  volume={16 11},
  pages={2082-91}
}
Aseptic loosening of orthopedic implants is thought to be caused primarily by osteoclast differentiation induced by bone resorptive cytokines produced in response to phagocytosis of implant-derived wear particles. This study examined whether adherent endotoxin on the wear particles is responsible for inducing osteoclast differentiation as well as production of interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor a (TNF-alpha). Removal of adherent endotoxin almost completely inhibited… CONTINUE READING
52 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…