Adherent Human Alveolar Macrophages Exhibit a Transient Pro-Inflammatory Profile That Confounds Responses to Innate Immune Stimulation

@inproceedings{Tomlinson2012AdherentHA,
  title={Adherent Human Alveolar Macrophages Exhibit a Transient Pro-Inflammatory Profile That Confounds Responses to Innate Immune Stimulation},
  author={Gillian S. Tomlinson and Helen Booth and Sarah J. Petit and Elspeth Potton and Greg J. Towers and Robert F. Miller and Benjamin M. Chain and Mahdad Noursadeghi},
  booktitle={PloS one},
  year={2012}
}
Alveolar macrophages (AM) are thought to have a key role in the immunopathogenesis of respiratory diseases. We sought to test the hypothesis that human AM exhibit an anti-inflammatory bias by making genome-wide comparisons with monocyte derived macrophages (MDM). Adherent AM obtained by bronchoalveolar lavage of patients under investigation for haemoptysis, but found to have no respiratory pathology, were compared to MDM from healthy volunteers by whole genome transcriptional profiling before… CONTINUE READING
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