Adherens junctions: from molecules to morphogenesis

  title={Adherens junctions: from molecules to morphogenesis},
  author={Tony J. C. Harris and Ulrich Tepass},
  journal={Nature Reviews Molecular Cell Biology},
How adhesive interactions between cells generate and maintain animal tissue structure remains one of the most challenging and long-standing questions in cell and developmental biology. Adherens junctions (AJs) and the cadherin–catenin complexes at their core are therefore the subjects of intense research. Recent work has greatly advanced our understanding of the molecular organization of AJs and how cadherin–catenin complexes engage actin, microtubules and the endocytic machinery. As a result… 

Structural and functional diversity of cadherin at the adherens junction

An evolutionary reconstruction of cadherin structure and function provides a comprehensive framework with which to appreciate the diversity of morphogenetic mechanisms in animals.

Cadherin-actin interactions at adherens junctions.

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The endo-exocytic traffic of integrins back and forth from the plasma membrane represents another crucial regulatory aspect in cell adhesion and motility.

Adherens junctions during cell migration.

Cadherin and nectin-based adherens junctions are key players in intercellular interactions, used as adhesive complexes whose mechanical properties improve cell coordination during collective migration and promote cell motility on cadherin substrates.

Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective.

An evolutionary perspective is taken on how the emergence of these two essential intercellular junctions at key points during the evolution of multicellular animals afforded metazoans with new opportunities to integrate adhesion, cytoskeletal dynamics, and signaling.

Maintenance of epidermal architecture by CLASP2 and p120-catenin

Overall, the work presented in this doctoral thesis supports a model where microtubule plus-ends are targeted to Adherens Junctions in basal keratinocytes via the CLASP2-p120 interaction whereas minus- ends are captured at cell-cell adhesion sites in differentiated cells.

Cell Biology: A Tense but Good Day for Actin at Cell–Cell Junctions




Actin dynamics and cell-cell adhesion in epithelia.

Junctional trafficking and epithelial morphogenesis.

Disassembling adherens junctions: breaking up is hard to do.

Regulation of cadherin-mediated adhesion in morphogenesis

  • B. Gumbiner
  • Biology, Medicine
    Nature Reviews Molecular Cell Biology
  • 2005
Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell

Remodeling of the adherens junctions during morphogenesis.

Cadherin dimers in cell-cell adhesion.

  • S. Troyanovsky
  • Biology, Materials Science
    European journal of cell biology
  • 2005

Catenins: keeping cells from getting their signals crossed.

Cadherin cell adhesion receptors as a morphogenetic regulator.

Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells. Through their homophilic binding interactions, cadherins play a role in cell-sorting

ROCK and Dia have opposing effects on adherens junctions downstream of Rho

Activation of the effector kinase ROCK and acto-myosin contraction disrupts AJs downstream of Rho, finding that signalling through the Rho effector Dia1 is required to ensure a dynamically stable interface between cells and the maintenance of adherens junction complexes.

Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila

The results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes.