Adherens junction-dependent PI3K/Akt activation induces resistance to genotoxin-induced cell death in differentiated intestinal epithelial cells.

@article{Chae2009AdherensJP,
  title={Adherens junction-dependent PI3K/Akt activation induces resistance to genotoxin-induced cell death in differentiated intestinal epithelial cells.},
  author={Boah Chae and Kyoung Min Yang and Tae Il Kim and Won Ho Kim},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={378 4},
  pages={
          738-43
        }
}
The crypt-villi axis of intestinal mucosa maintains homeostasis by renewal of epithelia, and also exhibits different properties from undifferentiated to terminally differentiated cells. We investigated differential susceptibility to genotoxin-induced cell death, based on the degree of differentiation of epithelial cells, and its mechanism. Differentiation was induced by post-confluence culture in Caco-2 cells. Methyl methanesulfonate (MMS), a direct-acting DNA alkylating agent, was used for… CONTINUE READING
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