Adherence to medication.

@article{Osterberg2005AdherenceTM,
  title={Adherence to medication.},
  author={Lars G Osterberg and Terrence F. Blaschke},
  journal={The New England journal of medicine},
  year={2005},
  volume={353 5},
  pages={
          487-97
        }
}
The full benefit of many effective medications will be achieved only if patients adhere to prescribed treatment regimens. Unfortunately, applying terms such as “noncompliant” and “nonadherent” to patients who do not consume every pill at the desired time can stigmatize them in their future relationships with health care providers. This article on medication adherence (or compliance) reviews strategies to assess and enhance this important aspect of patient care. 

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References

SHOWING 1-10 OF 154 REFERENCES
Adherence to treatment and health outcomes.
TLDR
It is now believed that the outcomes of treatment are not solely attributable to the specific action of a drug, but may also depend on other nonspecific therapeutic effects.
[Methods to improve patient compliance in the use of antidepressants].
TLDR
Research has shown that interventions that enhance compliance can lead to a better outcome of the depression and a structured treatment programme in which the patient actively participates can improve compliance.
Compliance declines between clinic visits.
TLDR
Data indicate that spot drug levels do not represent long-term "steady-state" drug serum concentrations, and adherence to prescribed drug dosing regimens declined substantially during the interval between clinic visits and drug level tests.
A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors
TLDR
Using HIV viral load as a clinical criterion, methods of measuring adherence to antiretroviral therapy among HIV-infected patients were compared, a composite adherence score (CAS) was developed, and the associations between each adherence measure and viral load were analyzed.
Measurement of Adherence to Antiretroviral Medications
TLDR
Measurement of adherence may be important in determining why patients fail antiretroviral therapy, and a composite adherence score has been developed that uses electronic monitoring, pill counts, and patient self‐report.
Associations with medication adherence among ethnically different pediatric patients with renal transplants
TLDR
Perceived characteristics of their medication regimen, including pill size, pill taste and medication complexity, were found to have significantly low to moderate associations with medication adherence among African American and European American pediatric renal transplant patients.
Overview of patient compliance with medication dosing: a literature review.
TLDR
Once- a-day and twice-a-day regimens were associated with significantly better compliance than were three- times-daily and four-times-daily regimens.
Compliance/adherence and care management in HIV disease.
  • M. Crespo-Fierro
  • Medicine, Political Science
    The Journal of the Association of Nurses in AIDS Care : JANAC
  • 1997
Adherence to HAART among patients with HIV: Breakthroughs and barriers
TLDR
Overall, multifaceted interventions appear most promising in adherence to HAART, with recommendations to enhance clinical practice and improve treatment outcomes for patients with HIV.
Hypertension and current issues in compliance and patient outcomes
TLDR
The use of health-related quality of life assessment in antihypertensive studies and in routine clinical practice provides another opportunity to optimize a patient’s regimen for short-and long-term hypertension control in a cost-effective manner.
...
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