Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection

@article{Paterson2000AdherenceTP,
  title={Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection},
  author={David Paterson and Susan Swindells and Jeffrey A. Mohr and Michelle Brester and Emanuel N. Vergis and Cheryl L Squier and M Wagener and Nina Singh},
  journal={Annals of Internal Medicine},
  year={2000},
  volume={133},
  pages={21-30}
}
Improved therapeutic strategies, including the introduction of protease inhibitors, have led to a striking decrease in HIV-related morbidity and mortality (1, 2). It is widely believed that adherence to an antiretroviral regimen is central to the likelihood that a patient will derive sustained benefit from therapy (3, 4). Conventional wisdom holds that two groups of patients are currently experiencing clinical and virologic failure. The first group consists of patients who have received… Expand
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  • Medicine
  • The Journal of infectious diseases
  • 2002
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Nonadherence to both MAC prophylaxis and antiretroviral therapy was associated with higher human immunodeficiency virus (HIV) type 1 RNA levels and a significant increase in the risk of developing an AIDS-defining complication or death. Expand
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Adherence to Protease Inhibitors
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Antiretroviral adherence, drug resistance, viral fitness and HIV disease progression: a tangled web is woven.
  • G. Lucas
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The clinical goals of HIV treatment are optimally accomplished through consistent high-level adherence to highly active antiretroviral therapy (HAART) and durable suppression of the viral load.Expand
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References

SHOWING 1-10 OF 41 REFERENCES
Adherence to antiretroviral regimens in HIV-infected patients: results of a survey among physicians and patients.
  • J. Gallant, D. Block
  • Medicine
  • Journal of the International Association of Physicians in AIDS Care
  • 1998
A DuPont Merck survey of patients and physicians addresses the issues of adherence to complex HIV antiretroviral therapy and suggests that simpler regimens could improve adherence. Adherence is notExpand
Potential factors affecting adherence with HIV therapy
A greatly increased level and duration of suppression of HIV replication has become possible with the use of protease inhibitors in combination with nucleoside analogues as antiretroviral therapyExpand
Improved survival among HIV-infected individuals following initiation of antiretroviral therapy.
TLDR
The HIV-infected individuals who receivedInitial therapy with regimens including stavudine or lamivudine had significantly lower mortality and longer AIDS-free survival than those who received initial therapy withregimens limited to zidovudine, didanosine, and zalcitabine. Expand
Public health implications of antiretroviral therapy and HIV drug resistance.
TLDR
Unless this topic is appropriately addressed, the likelihood is that drug-resistant variants of HIV, if able to successfully replicate, will sustain the epidemic and limit the effectiveness of antiviral therapy. Expand
Adherence to antiretroviral and pneumocystis prophylaxis in HIV disease.
  • L. Eldred, A. Wu, R. Chaisson, R. Moore
  • Medicine
  • Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
  • 1998
TLDR
A relatively low level of adherence to antiretroviral therapy and PCP prophylactic regimens was found, and these findings may have important implications for patients receiving highly active antireteviral therapy (HAART). Expand
Determinants of compliance with antiretroviral therapy in patients with human immunodeficiency virus: prospective assessment with implications for enhancing compliance.
TLDR
The prevalence and variables associated with compliance with antiretroviral therapy in patients with human immunodeficiency virus infection, by means of a longitudinal observational study of 46 patients aged 23 to 68 years, are assessed. Expand
Compliance with zidovudine therapy in patients infected with human immunodeficiency virus, type 1: a cross-sectional study in a municipal hospital clinic.
TLDR
High compliance with zidovudine was achieved by HIV-infected patients in a municipal hospital clinic, many of whom had a history of intravenous drug use and may be enhanced by a patient's belief that it prolongs life and the use of a medication timer for proper dosing. Expand
Measuring HIV treatment adherence in clinical practice.
TLDR
Questioning the patient with specific, nonjudgmental questions is the best method for gaining accurate information about adherence problems and enhancing regimen adherence. Expand
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection.
TLDR
A study was conducted to evaluate the impact of protease inhibitors on the rates of selected opportunistic processes and mortality in patients with AIDS and found similar results. Expand
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
TLDR
The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies. Expand
...
1
2
3
4
5
...