Adherence to HIV treatment among IDUs and the role of opioid substitution treatment (OST).

@article{Spire2007AdherenceTH,
  title={Adherence to HIV treatment among IDUs and the role of opioid substitution treatment (OST).},
  author={Bruno Spire and Gregory M. Lucas and Maria Patrizia Carrieri},
  journal={The International journal on drug policy},
  year={2007},
  volume={18 4},
  pages={
          262-70
        }
}
In the era of highly effective anti-retroviral therapy (ART), data show a significant difference in treatment outcomes between injecting drug users (IDUs) and non-IDUs. Factors that may contribute to suboptimal treatment outcomes in IDUs include delayed access to ART, competing comorbid diseases, psychosocial barriers and poor long-term adherence to ART. This review describes and compares several studies on adherence to ART and its correlates in HIV-infected individuals in general, then IDUs… Expand
Impact of opioid substitution therapy on the HIV prevention benefit of antiretroviral therapy for people who inject drugs
TLDR
OST could improve the HIV prevention benefit of ART; supporting strategies that aim to concurrently scale-up OST with ART are supported. Expand
Modelling the impact of opioid substitution therapy on the prevention benefit of antiretroviral therapy amongst people who inject drugs
Word count 250 Objective: A recent systematic review suggested that opioid substitution therapy (OST) increased uptake of anti-retroviral treatment (ART) and HIV viral suppression. We modelledExpand
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TLDR
Both access to and effectiveness of OST contribute to sustaining adherence to HAART in HIV-infected IDUs, and the need of wider use of O ST in countries scaling-up HAART where HIV is driven by IDUs is advocated. Expand
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TLDR
This chapter reviews accomplishments and discusses the opportunities and challenges facing the scale-up of HIV prevention technologies in regards to addressing the impact of substance use. Expand
Methadone maintenance therapy promotes initiation of antiretroviral therapy among injection drug users.
TLDR
It is demonstrated that MMT contributes to more rapid initiation and subsequent adherence to ART among opioid-using HIV-infected IDU, and addressing international barriers to the use and availability of methadone may increase dramatically uptake of HIV treatment among this population. Expand
Harm reduction intensity-Its role in HAART adherence amongst drug users in Amsterdam.
TLDR
In Amsterdam, still-injecting DU who are exposed to systematic and integrated care, although not practising complete harm reduction, can be just as adherent to HAART as DU who make use of complete harm Reduction and non-injectioning DU with no dependence on harm reduction. Expand
Retention in opioid substitution treatment: a major predictor of long-term virological success for HIV-infected injection drug users receiving antiretroviral treatment.
  • P. Roux, M. Carrieri, +4 authors B. Spire
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2009
TLDR
Increasing access to OST based on a comprehensive model of care for HIV-infected patients who have indications for OST may foster adherence and ensure long-term response to HAART and present important evidence of the positive impact of retention in OST on HIV outcomes. Expand
TREATMENT OF HIV INFECTION IN INJECTION DRUG USERS
TLDR
It is demonstrated that with nevirapine and efavirenz, moderate increases in methadone dosage were required to maintain the therapeutic benefit of opiate substitution therapy, compared to no change required in patients receiving regimens containing lopinavir or atazanavir. Expand
ADHERENCE TO METHADONE MAINTENANCE TREATMENT (MMT) AND ITS RELATED FACTORS IN WEST JAVA, INDONESIA
TLDR
This study found that patients with a history of negative HIV must be monitored to sustain its adherence to MMT program, and patients that had a diagnose of HIV positive and surrounded by somebody with which patients can share their life may lead to higher adherence. Expand
Eligibility for heroin-assisted treatment (HAT) among people who inject opioids and are living with HIV in a Canadian setting
TLDR
Eligibility for heroin-assisted treatment was linked to risk factors for sub-optimal HIV/AIDS treatment outcomes, such as homelessness and involvement in the local illicit drug trade, suggesting that scaling-up access to HAT might contribute to achieving optimal HIV treatment in this setting. Expand
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