Adherence in the CAPRISA 004 Tenofovir Gel Microbicide Trial

@article{Mansoor2014AdherenceIT,
  title={Adherence in the CAPRISA 004 Tenofovir Gel Microbicide Trial},
  author={Leila E Mansoor and Quarraisha Abdool Karim and Nonhlanhla Yende-Zuma and Kathleen M. MacQueen and Cheryl Baxter and Bernadette T. Madlala and Anneke C. Grobler and Salim S. Abdool Karim},
  journal={AIDS and Behavior},
  year={2014},
  volume={18},
  pages={811-819}
}
High adherence is key to microbicide effectiveness. Here we provide a description of adherence interventions and the adherence rates achieved in the CAPRISA 004 Tenofovir gel trial. Adherence support for the before-and-after dosing strategy (BAT 24) was provided at enrolment and at each monthly study visit. This initially comprised individual counselling and was replaced midway by a structured theory-based adherence support program (ASP) based on motivational interviewing. The 889 women were… CONTINUE READING