Adequate tumour quinidine levels for multidrug resistance modulation can be achieved in vivo.

Abstract

The multidrug resistance (MDR) phenotype can be reversed in vitro by a number of agents thought to interact with P-glycoprotein (P-gp). Although plasma levels, adequate for MDR modulation, can be achieved with certain modulators, concern has been expressed that tumour levels may be inadequate due to high plasma protein binding. Mice bearing an MDR-positive… (More)

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Cite this paper

@article{Wishart1992AdequateTQ, title={Adequate tumour quinidine levels for multidrug resistance modulation can be achieved in vivo.}, author={Gordon C. Wishart and Jane A. Plumb and J Gil Morrison and Tod G Hamilton and Stanley B. Kaye}, journal={European journal of cancer}, year={1992}, volume={28 1}, pages={28-31} }