Adequacy of single-locus approximations for linkage analyses of oligogenic traits.

@article{Vieland1992AdequacyOS,
  title={Adequacy of single-locus approximations for linkage analyses of oligogenic traits.},
  author={Veronica J. Vieland and Susan E. Hodge and David Greenberg},
  journal={Genetic epidemiology},
  year={1992},
  volume={9 1},
  pages={45-59}
}
When a disease is controlled by two or more mendelian loci acting epistatically, it can be modeled in a linkage analysis as a single-locus mendelian disease with reduced penetrance. However, the reliability of such an approximation has not yet been demonstrated. This study evaluates the adequacy of such single-locus approximations, when the disease under investigation is determined by two loci, one of which is tightly linked to a genetic marker. A wide range of two-locus models were simulated… CONTINUE READING

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