Adenylylation, MS, and proteomics--Introducing a "new" modification to bottom-up proteomics.

@article{Hansen2013AdenylylationMA,
  title={Adenylylation, MS, and proteomics--Introducing a "new" modification to bottom-up proteomics.},
  author={Terkel Hansen and Michel Albers and Christian Hedberg and Albert Sickmann},
  journal={Proteomics},
  year={2013},
  volume={13 6},
  pages={955-63}
}
Although the addition of a 5'-adenosine phosphodiester group to proteins, called adenylylation, has been known for decades, the possibility that adenylylation could be a molecular switch in cellular signaling pathways has emerged recently. The distinct mass shift upon adenylation of threonine or tyrosine residues renders it a good target for MS detection and identification; however, the fragmentation of adenylylated peptides derived from proteolytic digestion of adenylylated proteins has not… CONTINUE READING

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