Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step.

@article{Chotiner2003AdenylylCF,
  title={Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step.},
  author={Jennifer K Chotiner and Hooman Khorasani and Angus C. Nairn and Thomas J O'Dell and Joseph C. Watson},
  journal={Neuroscience},
  year={2003},
  volume={116 3},
  pages={743-52}
}
The persistent maintenance of long-term potentiation requires both messenger RNA and protein synthesis. While there is mounting evidence for an active role of protein synthesis in hippocampal long-term potentiation, the nature of mechanisms underlying its regulation has not yet been established. We used a previously described chemical long-term potentiation protocol [J Neurosci 19 (1999) 2500] to address the hypothesis that signaling mechanisms, involved in long-lasting long-term potentiation… CONTINUE READING

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