Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.

@article{Roos2013AdenylylCV,
  title={Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.},
  author={Karl P Roos and Vladislav Bugaj and Elena A. Mironova and James D Stockand and Nirupama Ramkumar and Sara Rees and Donald E Kohan},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2013},
  volume={24 2},
  pages={
          218-27
        }
}
Vasopressin modulates sodium reabsorption in the collecting duct through adenylyl cyclase-stimulated cyclic AMP, which exists as multiple isoforms; the specific isoform involved in vasopressin-stimulated sodium transport is unknown. To assess this, we studied mice deficient in adenylyl cyclase type VI specifically in the principal cells of the collecting duct. Knockout mice had increased urine volume and reduced urine sodium concentration, but regardless of the level of sodium intake, they did… CONTINUE READING
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