Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC.

@article{Rieg2013AdenylylC6,
  title={Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC.},
  author={Timo Rieg and Tong Yu Tang and Shinichi Uchida and H Kirk Hammond and Robert Andrew Fenton and Volker Vallon},
  journal={The American journal of pathology},
  year={2013},
  volume={182 1},
  pages={96-106}
}
Arginine vasopressin (AVP) affects kidney function via vasopressin V2 receptors that are linked to activation of adenylyl cyclase (AC) and an increase in cyclic adenosine monophosphate formation. AVP/cyclic adenosine monophosphate enhance the phosphorylation of the Na-K-2Cl cotransporter (NKCC2) at serine residue 126 (pS126 NKCC2) and of the Na-Cl cotransporter (NCC) at threonine 58 (pT58 NCC). The isoform(s) of AC involved in these responses, however, were unknown. Phosphorylation of S126… CONTINUE READING

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