Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.

@article{Wang2018AdenylylC5,
  title={Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.},
  author={Qian Wang and Patricia Cobo-Stark and Vishal Patel and Stefan Somlo and Pyung-Lim Han and Peter Igarashi},
  journal={Kidney international},
  year={2018},
  volume={93 2},
  pages={403-415}
}
Cyclic AMP promotes cyst growth in polycystic kidney disease (PKD) by stimulating cell proliferation and fluid secretion. Previously, we showed that the primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase anchoring protein 150, protein kinase A, and… CONTINUE READING