Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling.

@article{Dessauer2009AdenylylCA,
  title={Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signaling.},
  author={Carmen W. Dessauer},
  journal={Molecular pharmacology},
  year={2009},
  volume={76 5},
  pages={935-41}
}
The formation of multiprotein complexes is a repeated theme in biology ranging from the regulation of the extracellular signal-regulated kinase and cAMP signaling pathways to the formation of postsynaptic density complexes or tight junctions. A-kinase anchoring proteins (AKAPs) are well known for their ability to scaffold protein kinase A and components upstream and downstream of cAMP production, including G protein-coupled receptors, cAMP-dependent Rap-exchange factors, and phosphodiesterases… CONTINUE READING
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