Adenylyl Cyclases 1 and 8 Initiate a Presynaptic Homeostatic Response to Ethanol Treatment

@article{Conti2009AdenylylC1,
  title={Adenylyl Cyclases 1 and 8 Initiate a Presynaptic Homeostatic Response to Ethanol Treatment},
  author={Alana C. Conti and James W. Jr. Maas and Krista L. Moulder and Xiaoping Jiang and Bhumy A. Dav{\'e} and Steven J Mennerick and Louis J. Muglia},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={4118 - 4126}
}
BACKGROUND Although ethanol exerts widespread action in the brain, only recently has progress been made in understanding the specific events occurring at the synapse during ethanol exposure. Mice deficient in the calcium-stimulated adenylyl cyclases, AC1 and AC8 (DKO), demonstrate increased sedation duration and impaired phosphorylation by protein kinase A (PKA) following acute ethanol treatment. While not direct targets for ethanol, we hypothesize that these cyclases initiate a homeostatic… CONTINUE READING