Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.

@article{Gordon1989AdenylateCT,
  title={Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.},
  author={Victor M. Gordon and William W. Young and S M Lechler and Mary C. Gray and Stephen H Leppla and Erik L. Hewlett},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 25},
  pages={14792-6}
}
Adenylate cyclase (AC) toxins produced by Bacillus anthracis and Bordetella pertussis were compared for their ability to interact with and intoxicate Chinese hamster ovary cells. At 30 degrees C, anthrax AC toxin exhibited a lag of 10 min for measurable cAMP accumulation that was not seen with pertussis AC toxin. This finding is consistent with previous data showing inhibition of anthrax AC toxin but not pertussis AC toxin entry by inhibitors of receptor-mediated endocytosis (Gordon, V. M… CONTINUE READING