Adenylate cyclase and protein kinase C mediate opposite actions on endothelial junctions.

@article{Oliver1990AdenylateCA,
  title={Adenylate cyclase and protein kinase C mediate opposite actions on endothelial junctions.},
  author={Juan A. Oliver},
  journal={Journal of cellular physiology},
  year={1990},
  volume={145 3},
  pages={536-42}
}
To determine whether the endothelial paracellular pathway is regulated, the effect of intracellular messengers on the transendothelial flux of inert radiolabeled molecules of diverse molecular size was examined in bovine aortic endothelial cells grown on collagen-coated filters. The endothelial monolayers showed a modest electrical resistance (21 +/- 10 delta.cm2; m +/- SD) and restricted the passage to 14C-sucrose, 3H-inulin, 14C-dextran (70 kDa), and 125I-polyvinyl pyrrolidone (125I-PVP, 360… CONTINUE READING
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