Adenylate cyclase and calmodulin-dependent kinase have opposite effects on osteoclastogenesis by regulating the PKA-NFATc1 pathway.

Abstract

Nuclear factor of activated T cells c1 (NFATc1) is a transcription factor crucial for the differentiation of osteoclasts. In this study we discovered new signaling pathways involving cAMP regulators that modulate NFATc1 during osteoclastogenesis. The osteoclast differentiation factor receptor activator of NF-κB ligand (RANKL) increased the expression of… (More)
DOI: 10.1002/jbmr.310

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Cite this paper

@article{Yoon2011AdenylateCA, title={Adenylate cyclase and calmodulin-dependent kinase have opposite effects on osteoclastogenesis by regulating the PKA-NFATc1 pathway.}, author={Soo-Hyun Yoon and Ji yoon Ryu and Youngkyun Lee and Zang Hee Lee and Hong-Hee Kim}, journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research}, year={2011}, volume={26 6}, pages={1217-29} }