Corpus ID: 25387668

Adenylate cyclase activity of synaptic membranes from rat striatum. Inhibition by muscarinic receptor agonists.

  title={Adenylate cyclase activity of synaptic membranes from rat striatum. Inhibition by muscarinic receptor agonists.},
  author={Maria C. Olianas and Pierluigi Onali and Norton H. Neff and Erminio Costa},
  journal={Molecular pharmacology},
  volume={23 2},
Acetylcholine inhibits, by 30-40%, the basal adenylate cyclase activity of purified synaptic plasma membranes prepared from rat striatum (EC50 = 3 microM). Cholinergic receptor agonists inhibit this cyclase activity with the following rank order of potency: oxtremorine greater than acetylcholine greater than arecoline greater than methacholine greater than or equal to muscarine greater than or equal to carbachol greater than bethanechol. Nicotine fails to inhibit the cyclase, and d-tubocurarine… Expand
The Muscarinic Receptor Adenylate Cyclase Complex of Rat Striatum: Desensitization Following Chronic Inhibition of Acetylcholinesterase Activity
The desensitization of the muscarinic receptor adenylate cyclase complex was associated with a marked attenuation of the capacity of ACh to stimulate a high‐affinity GTPase activity present in striatal membranes. Expand
Positive coupling of cholinergic muscarinic receptors to adenylate cyclase activity in membranes of rat olfactory bulb
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Muscarinic Receptors Modulate Dopamine‐Activated Adenylate Cyclase of Rat Striatum
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Pertussis Toxin Attenuates D2 Inhibition and Enhances D1 Stimulation of Adenylate Cyclase by Dopamine in Rat Striatum
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Modulation of adenylate cyclase activity by GABAB receptors
Abstract Radioligand binding to bicuculline-insensitive GABAB receptors has been shown to be modulated by GTP. In many systems this reflects a link with adenylate cyclase. Consequently the effects ofExpand
Muscarinic cholinergic inhibition of adenylate cyclase in airway smooth muscle.
The results suggest that one biochemical effect of vagal stimulation in the central airways of dogs may be attenuated adenylate cyclase activity in the smooth muscle. Expand
B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity
  • P. Onali, M. Olianas
  • Biology, Medicine
  • Journal of Neural Transmission / General Section JNT
  • 2005
Results indicate that B-HT 920 is capable of activating DA D2 receptors negatively coupled to adenylate cyclase activity and counteracted by the dopamine D2 receptor antagonist 1-sulpiride, but not by the α2-adrenergic antagonist yohimbine. Expand
Supersensitivity of striatal D2 dopamine receptors mediating inhibition of adenylate cyclase and stimulation of guanosine triphosphatase following chronic administration of haloperidol in mice
Results indicate that D2 receptors linked to inhibition of adenylate cyclase and to stimulation of GTPase become supersensitive following in vivo chronic blockade of DA receptors. Expand
Muscarinic acetylcholine receptor activation causes inhibition of cyclic AMP accumulation, prolactin and growth hormone secretion in GH3 rat anterior pituitary tumour cells.
The results suggest that the inhibition of hormone secretion from GH3 cells by muscarinic agonists is mediated by a decrease in intracellular cyclic AMP levels. Expand
Effects of oxotremorine and RMI 12330 A on [3H]acetylcholine release and adenylate cyclase activity in guinea pig superior cervical ganglion
Results indicate that drugs capable of inhibiting adenylate cyclase, significantly decrease ACh output from preganglionic nerve terminals in guinea pig SCG. Expand