Adenylate cyclase activity of synaptic membranes from rat striatum. Inhibition by muscarinic receptor agonists.

@article{Olianas1983AdenylateCA,
  title={Adenylate cyclase activity of synaptic membranes from rat striatum. Inhibition by muscarinic receptor agonists.},
  author={Maria C. Olianas and Pierluigi Onali and Norton H. Neff and Erminio Costa},
  journal={Molecular pharmacology},
  year={1983},
  volume={23 2},
  pages={393-8}
}
Acetylcholine inhibits, by 30-40%, the basal adenylate cyclase activity of purified synaptic plasma membranes prepared from rat striatum (EC50 = 3 microM). Cholinergic receptor agonists inhibit this cyclase activity with the following rank order of potency: oxtremorine greater than acetylcholine greater than arecoline greater than methacholine greater than or equal to muscarine greater than or equal to carbachol greater than bethanechol. Nicotine fails to inhibit the cyclase, and d-tubocurarine… CONTINUE READING
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