Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence.

@article{Hritonenko2011AdenylateCA,
  title={Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence.},
  author={Victoria Hritonenko and James J. Mun and Connie Tam and Nathan C. Simon and Joseph T. Barbieri and David W Evans and Suzanne M. J. Fleiszig},
  journal={Microbial pathogenesis},
  year={2011},
  volume={51 5},
  pages={305-12}
}
We previously showed that ADP-ribosylation (ADP-r) activity of ExoS, a type III secreted toxin of Pseudomonas aeruginosa, enables bacterial replication in corneal and respiratory epithelial cells and correlates with bacterial trafficking to plasma membrane blebs (bleb-niche formation). Here, we explored another type III secreted toxin, ExoY, for its impact on intracellular trafficking and survival, and for virulence in vivo using a murine corneal infection model. Chromosomal or plasmid-mediated… CONTINUE READING

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