Adenylate and guanylate cyclase activities and cellular differentiation in rat small intestine.

@article{Quill1975AdenylateAG,
  title={Adenylate and guanylate cyclase activities and cellular differentiation in rat small intestine.},
  author={Helen Quill and Milton M. Weiser},
  journal={Gastroenterology},
  year={1975},
  volume={69 2},
  pages={
          470-8
        }
}
Adenylate and guanylate cyclase activities were measured in rat small intestinal villus and crypt cells to determine possible correlations with cellular differentiation. Isolated intestinal cells were prepared by a method which effectively separates differentiated villus cells from undifferentiated crypt cells (J Biol Chem 248:2542, 1973). Crypt cells were found to have a significantly lower guanylate cyclase activity than villus cells. Adenylate cyclase activity was higher in crypt cells than… CONTINUE READING

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